Last Friday, NRx’s stock closed at $8.52. Nevertheless, after announcing astonishing news, it is crashing market: the stock is currently at $15.5 in pre-market, resulting in a tremendous 82% growth. The presentation identifies a statistically significant effect of ZYESAMI (aviptadil) in stopping the rise in cytokines, commonly associated with mortality in patients with COVID-19. In the recently completed phase 2b/3 trial, patients treated with placebo had a statistically important elevation in interleukin 6 (IL-6) cytokine levels, whereas those treated with ZYESAMI had a small increase in IL-6.
Health regulators continue to prioritize therapies for COVID-19 which help to stop the impact of IL-6 cytokines in patients with COVID-19. The anti-cytokine effect of ZYESAMI™ was additionally associated with a significant decline in 60-day mortality.
The cytokine data was collected as part of the Phase 2b/3 trial of ZYESAMI compared to placebo, in critically ill patients with COVID-19 respiratory failure. The effect was noted across a wide range of patients, suffering various levels of COVID-19 severity and treated in both tertiary care and local hospitals.
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